Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells
نویسندگان
چکیده
منابع مشابه
Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells.
Low levels of telomerase activity have recently been detected in human primitive hematopoietic cells, however, blood cells exhibit telomere shortening on cell proliferation. This challenging observation led us to study telomerase regulation and telomere length in human hematopoietic progenitor cells from fetal liver (FL), cord blood (CB), peripheral blood (PB), and bone marrow (BM). We found te...
متن کاملDissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells.
Primitive human hematopoietic cells have low endogenous telomerase activity, yet telomeres are not maintained. In contrast, ectopic telomerase expression in fibroblasts and other cells leads to telomere length maintenance or elongation. It is unclear whether this disparity can be attributed to telomerase level or stems from fundamentally different telomere biology. Here, we show that telomerase...
متن کاملCell cycle regulation in hematopoietic stem cells
This review focuses on the cell cycle of hematopoietic stem cell and its regulatory mechanisms. Owing to recent advances in cell culture techniques and analyzing tools, hematopoietic stem cells can be purified from bone marrow, peripheral blood, and umbilical cord blood by using specific surface markers such as Sca-1 (murine) and CD34 (human). Stem cell compartment includes primitive stem cells...
متن کاملCell-cycle-dependent telomere elongation by telomerase in budding yeast.
Telomeres are essential for the stability and complete replication of linear chromosomes. Telomere elongation by telomerase counteracts the telomere shortening due to the incomplete replication of chromosome ends by DNA polymerase. Telomere elongation is cell-cycle-regulated and coupled to DNA replication during S-phase. However, the molecular mechanisms that underlie such cell-cycle-dependent ...
متن کاملTelomere and telomerase stability in human diseases and cancer.
Telomeres are the nucleoprotein structures at the end of linear eukaryotic chromosomes required for genome stability. Telomerase is the specialized enzyme deputed to their elongation. Maintenance of a proper telomere structure, an accurate regulation of telomerase biogenesis and activity, as well as a correct telomere-telomerase interaction and a faithful telomeric DNA replication are all proce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v90.1.182